Immunology and Infection by Protozoan Parasites By Edecio Cunha-Neto, Christophe Chevillard

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Immunology and Infection by Protozoan Parasites Pdf Book

Introduction: Immunology

Protozoan infection is the cause of diseases (Immunology) of high morbidity and mortality. Most are non-self-limiting chronic infections and neglected diseases; emergent antimicrobial-resistant strains pose a substantial problem; for many of the treatment either is highly toxic or has limited effectiveness. Vaccine development is still a formidable task and there is no licensed vaccine for human protozoan infection. The key to the control of protozoan infection is the understanding of the host immune response to protozoan parasites is Immunology, which will guide the development of effective vaccines and immunotherapeutic agents. In this special issue, there are important studies on the immunology of T. cruzi infection, tegumentary and visceral leishmaniasis, malaria, and toxoplasmosis, both in patients and in animal models, which promote the understanding of immunopathological/immunoprotective parameters in these diseases.

The reviews of book Immunology by J. M. Alvarez and colleagues and by E. ´ Cunha-Neto and C. Chevillard cover fundamental findings, mechanisms, and questions concerning the immune response
and pathology of mouse and human disease. In this line, L. G. Nogueira and colleagues characterize the myocardial expression of transcriptional factors involved in effector
CD4+ T cell differentiation and the characteristic cytokines produced by the distinct lymphocyte subsets and demonstrate a profound predominance of local Th1 response. L.
C. J. Abel and coworkers characterized the proinflammatory effects of glicophosphatidyl inositol-anchored T. cruzi mucin (GPI-mucins) on human immune cells

Contents

Immunology and Infection by Protozoan Parasites
Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection
Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil
Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptor
Insulin-Like Growth Factor-I Induces Arginase Activity in Leishmania amazonensis Amastigote-Infected Macrophages through a Cytokine-Independent Mechanism
Trypanosoma cruzi Infection and Host Lipid Metabolism
Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice, Luana S. Ortolan, Michelle K
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum
TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA
Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice
Chagas Disease Cardiomyopathy: Immunopathology and Genetics
IL-17-Expressing CD4+ and CD8+ T Lymphocytes in Human Toxoplasmosis
Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response
The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice
Myocardial Gene Expression of T-bet, GATA-3, Ror-𝛾t, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response
Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease
Circumsporozoite Protein-Specific Kd-Restricted CD8+ T Cells Mediate Protective Antimalaria Immunity in Sporozoite-Immunized MHC-I-Kd Transgenic Mice
Innate Immunity to Leishmania Infection: Within Phagocytes,
Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens
Chagas Disease: Still Many Unsolved Issues
Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma
Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages
Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites

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